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CME / ABIM MOC

Exploring the Spectrum of Rett Syndrome: Diagnosis, Symptom Burden, and Care

  • Authors: Constance L. Smith-Hicks, MD, PhD; Alan K. Percy, MD; Jeffrey Neul, MD, PhD
  • CME / ABIM MOC Released: 3/7/2023
  • THIS ACTIVITY HAS EXPIRED FOR CREDIT
  • Valid for credit through: 3/7/2024, 11:59 PM EST
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Target Audience and Goal Statement

This activity is intended for neurologists, pediatricians, primary care physicians (PCPs), and other clinicians who treat patients with Rett syndrome.

The goal of this activity is for learners to be better able to assess for and diagnose Rett syndrome and to increase their knowledge of clinical data on therapies being studied for the management of Rett syndrome.

Upon completion of this activity, participants will:

  • Have increased knowledge regarding the
    • Presenting symptoms frequently associated with Rett syndrome
    • Diagnostic criteria for Rett syndrome
    • Clinical data on emerging treatments for the management of Rett syndrome
    • Current approaches to treating specific symptoms of Rett syndrome
  • Demonstrate greater confidence in their ability to
    • Assess and diagnose Rett syndrome


Disclosures

Medscape, LLC requires every individual in a position to control educational content to disclose all financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

All relevant financial relationships for anyone with the ability to control the content of this educational activity are listed below and have been mitigated. Others involved in the planning of this activity have no relevant financial relationships.

Disclosures for additional planners can be found here.


Faculty

  • Constance L. Smith-Hicks, MD, PhD

    Associate Professor of Neurology
    Johns Hopkins University School of Medicine
    Kennedy Krieger Institute
    Baltimore, Maryland

    Disclosures

    Participation by Dr. Constance L. Smith-Hicks does not constitute or imply endorsement by the Johns Hopkins University or the Johns Hopkins Hospital and Health System.

    Constance L. Smith-Hicks, MD, PhD, has no relevant financial relationships.

  • Alan K. Percy, MD

    Professor of Pediatrics, Neurology, Neurobiology, Genetics, and Psychology-Emeritus
    Sarah Katherine Bateh Endowed Professorship for Rett Syndrome-Emeritus
    University of Alabama at Birmingham
    Birmingham, Alabama

    Disclosures

    Alan K. Percy, MD, has the following relevant financial relationships:
    Consultant or advisor for: ACADIA Pharmaceuticals Inc.; Neurogene
    Contracted researcher for: ACADIA Pharmaceuticals Inc.

  • Jeffrey Neul, MD, PhD

    Professor of Pediatrics
    Division of Neurology, Pharmacology, and Special Education
    Annette Schaffer Eskind Chair
    Director
    Vanderbilt Kennedy Center
    Vanderbilt University Medical Center
    Nashville, Tennessee

    Disclosures

    Jeffrey Neul, MD, PhD, has no relevant financial relationships.

Editors

  • Pakinam Aboulsaoud, PharmD

    Senior Medical Education Director, Medscape, LLC

    Disclosures

    Pakinam Aboulsaoud, PharmD, has no relevant financial relationships.

  • Megan Breuer, PhD

    Medical Writer, Medscape, LLC

    Disclosures

    Megan Breuer, PhD, has the following relevant financial relationships:
    Consultant/advisor for: Paratek Pharmaceuticals, Inc. (former)
    Owns stock in (publicly traded): Bristol Myers Squibb Company; Johnson and Johnson; Paratek Pharmaceuticals, Inc.; Vertex Pharmaceuticals Incorporated

Compliance Reviewer

  • Amanda Jett, PharmD, BCACP

    Associate Director, Accreditation and Compliance, Medscape, LLC

    Disclosures

    Amanda Jett, PharmD, BCACP, has no relevant financial relationships.

Peer Reviewer

This activity has been peer reviewed and the reviewer has no relevant financial relationships.


Accreditation Statements

Medscape

Interprofessional Continuing Education

In support of improving patient care, Medscape, LLC is jointly accredited with commendation by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    For Physicians

  • Medscape, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Aggregate participant data will be shared with commercial supporters of this activity.

    Contact This Provider

For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]


Instructions for Participation and Credit

There are no fees for participating in or receiving credit for this online educational activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid credit period that is noted on the title page. To receive AMA PRA Category 1 Credit™, you must receive a minimum score of 70% on the post-test.

Follow these steps to earn CME/CE credit*:

  1. Read about the target audience, learning objectives, and author disclosures.
  2. Study the educational content online or print it out.
  3. Online, choose the best answer to each test question. To receive a certificate, you must receive a passing score as designated at the top of the test. We encourage you to complete the Activity Evaluation to provide feedback for future programming.

You may now view or print the certificate from your CME/CE Tracker. You may print the certificate, but you cannot alter it. Credits will be tallied in your CME/CE Tracker and archived for 6 years; at any point within this time period, you can print out the tally as well as the certificates from the CME/CE Tracker.

*The credit that you receive is based on your user profile.

CME / ABIM MOC

Exploring the Spectrum of Rett Syndrome: Diagnosis, Symptom Burden, and Care

Authors: Constance L. Smith-Hicks, MD, PhD; Alan K. Percy, MD; Jeffrey Neul, MD, PhDFaculty and Disclosures
THIS ACTIVITY HAS EXPIRED FOR CREDIT

CME / ABIM MOC Released: 3/7/2023

Valid for credit through: 3/7/2024, 11:59 PM EST

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Since this program has been written, the FDA has approved trofinetide oral solution indicated for the treatment of Rett syndrome in adults and pediatric patients 2 years of age and older [Trofinetide [prescribing information] Approved 2023. Revised March 2023].

Contents of This CME Activity

All sections of this activity are required for credit.

Symptoms, Stages, and Related Burden of Rett Syndrome

Dr Smith-Hicks discusses the symptoms and stages of Rett syndrome and the related burden of disease on individuals with the condition.
Constance L. Smith-Hicks, MD, PhD

Making the Diagnosis of Rett Syndrome and Ruling Out Differential Diagnoses

Dr Percy explains how clinicians can make a diagnosis of Rett syndrome and rule out other conditions that may mimic the syndrome.
Alan K. Percy, MD

Current and Emerging Therapeutic Approaches in Rett Syndrome

Dr Neul discusses current and upcoming therapeutic options for individuals with Rett syndrome.
Jeffrey Neul, MD, PhD
 

Educational Impact Challenge

The goal of this activity is for learners to be better able to assess for and diagnose Rett syndrome and to increase their knowledge of clinical data on therapies being studied for the management of Rett syndrome.

Before you begin this activity, please assess your clinical knowledge by completing this brief survey. Answering these questions again after the activity will allow you to see what you learned and to compare your answers with those of your peers.

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